Cephem compound

A compound of Formula (I):

• or an amino-protected compound when the amino group is present on the ring in the 7-side chain, or a pharmaceutically acceptable salt thereof,
• wherein
• W is —CH2—,—S— or—O—,
• a) U is —CH2—, —S—, —S(═O)— or —O—, when W is —CH2—;
• or,
• b) U is —CH2—, when W is —S— or —O—;
• L is substituted or unsubstituted lower alkylene or substituted or unsubstituted lower alkenylene;
• R1 is substituted or unsubstituted carbocyclyl or substituted or unsubstituted heterocyclyl;
• with regard to R2A and R2B,
• a) R2A is a hydrogen atom, substituted or unsubstituted amino, —SO3H, substituted or unsubstituted amino sulfonyl, carboxy, substituted or unsubstituted lower alkyloxycarbonyl, substituted or unsubstituted carbamoyl, hydroxy, or substituted carbonyloxy;
• and R2B is a hydrogen atom, or
• b) R2A and R2B are taken together to form substituted or unsubstituted methylidene, or substituted or unsubstituted hydroxyimino;
• R3 is a hydrogen atom, —OCH3 or —NH—CH(═O);
• R1 is carboxylate anion (—COO−) or a bioisoster of carboxylate anion (—COO−);
• E is a substituted or unsubstituted divalent group containing quaternary ammonium ion(s);
• G is a single bond, substituted or unsubstituted lower alkylene, substituted or unsubstituted lower alkenylene, or substituted or unsubstituted lower alkynylene;
• D is a single bond, —C(═O)—, —O—C(═O)—, —C(═O)—O—, —NR6—C(═O)—, —C(═O)—NR6—, —C(═O)—C(═O)—NR6—, —NR6—C(═O)—C(═O)—, —C(═O)—NR6—C(═O)—, —C(═O)—C(═O)—, —O—, —NR6—NR6—C(═O)—, —C(═O)—NR6—NR6—, —N═N—C(═O)—, —C(═O)—N═N—, —C═N—NR6—C(═O)—, —C═N—C(═O)—, —N═CR6—C(═O)—, —C═N—C(═O)—NR6—, —NR6—C(═O)—C(═N—OR6)—, —C(═N—OR6)—C(═O)—NR6—, —NR6—C(═N—OR6)—, —C(═N—OR6)—NR6—, —C(═O)—C(═N—OR6)—, —C(═N—OR6)—C(═O)—, —S—, —S(═O)—, —S(═O)2—NR6—, —NR6—S(═O)2—, —NR6—CH2—, —CH2—NR6—, —S(═O)2— or —NR6—;
• R6 is independently a hydrogen atom or substituted or unsubstituted lower alkyl;
• R10 is
• 1) substituted or unsubstituted phenyl or substituted or unsubstituted 6-membered heterocyclyl containing 1-3 nitrogen atoms;
• 2) substituted or unsubstituted 9-membered bicyclic aromatic heterocyclyl;
• or
• 3) a group represented by Formula:
• wherein
• ring B is substituted or unsubstituted carbocycle or substituted or unsubstituted heterocycle;
• Y is —C(═O)— or —S(═O)2—;
• Q is independently —O—, —S—, —NR—, —CR8R9—, —C(═O)—, —S(═O)2— or —N═CH—;
• R8 and R9 are each independently a hydrogen atom or substituted or unsubstituted lower alkyl;
• m is an integer from 1 to 3,
• provided that,
• a) D is —C(═O)—C(═O)—NR6—, —NR6—C(═O)—C(═O)—, —C(═O)—NR6—C(═O)—, —NR6—NR6—C(═O)—, —C(═O)—NR6—NR6—, —N═N—C(═O)—, —C(═O)—N═N—, —C═N—NR6—C(═O)—, —C═N—C(═O)—, —N═CR6—C(═O)—, —C═N—C(═O)—NR6—, —NR6—C(═O)—C(═N—OR6)—, —C(═N—OR6)—C(═O)—NR6—, —NR6—C(═N—OR6)—, —C(═N—OR6)—NR6—, —C(═O)—C(═N—OR6)—, —C(═N—OR6)—C(═O)—, or —C(═O)—C(═O)—, when R10 is the above 1);
• b) R10 is not a group represented by Formula:
• wherein the above ring is optionally substituted by one or more substituents selected from hydroxy, chloro, fluoro, bromo, carboxy and methoxy;
• and
• c) the compounds
• wherein R10 is the above 2) or 3),
• E is the group represented by Formula:
• wherein p is an integer form 1 to 3, and
• D is —NR6—C(═O)—, are excluded.