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US 2015/0343018 A1Published application
Nod2-dependent pathway of cytoprotection of stem cells
AssigneeInstitut Pasteur
InventorsPhilippe Sansonetti, Giulia Nigro
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AssigneeInstitut Pasteur
InventorsPhilippe Sansonetti, Giulia Nigro
Estimating the term…
The present invention is directed to an agonist of NOD2 for use in therapy for increasing the autonomous capacity of survival of vertebrate adult stem cells, without loss of their capacity to multiply and differentiate, and preferably the capacity of survival of intestinal stem cells, especially in response to a stress. The invention also concerns the use of an agonist of Nod2 for increasing in vitro or ex vivo the autonomous capacity of survival, without loss of multiplication and differentiation capacity of mammalian adult stem cell. The invention also discloses different media and support for mammalian adult stem cells. The invention also concerns an in vitro screening process for identifying molecules capable increasing, in response to a stress, the autonomous capacity of survival, without loss of multiplication and differentiation capacity of mammalian adult stem cells.
Agonist of NOD2 for use in therapy for increasing the autonomous capacity of survival of mammalian adult stem cells, without loss of their capacity to multiply and differentiate.
Agonist of NOD2 for use in transplantation of mammalian adult stem cells, for improving engraftment of said cells and tissue regeneration.
10-15. (canceled)
In vitro screening process for identifying molecules capable of increasing, in response to a stress, the autonomous capacity of survival of mammalian adult stem cells, without loss of their capacity to multiply and differentiate, comprising:
Dependencies are inferred from the claim text.