Theragnostic Particles
AssigneeUniversity of Washington through its Center for Commercialization
InventorsCarlos Enrique CATALANO, Jenny Ren-Jye CHANG
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Abstract
The present invention provides viral-based nanoparticles for therapeutic and diagnostic use, and methods for making and using the nanoparticles. Specifically, such nanoparticles comprise decoration-competent viral particles shells such as expanded capsids of phages, stabilized with engineered decoration proteins that have been linked to one or more compounds not naturally occurring on a wild type viral capsid.
Claims21
A theragnostic particle, comprising a plurality of engineered decoration proteins bound to an outer surface of decoration competent viral particle shell, wherein the engineered decoration proteins comprise decoration proteins linked to one or more compound not naturally occurring on a wild type viral capsid, and wherein the one or more compounds have at least one feature selected from the group consisting of:
- (a) the one or more compounds are non-proteinaceous compounds;
- (b) the one or more compounds are present on the theragnostic particle in a defined ratio relative to the engineered decoration protein;
- (c) the one or more compounds comprise two or more different compounds, wherein the two or more different compounds are present on the theragnostic particle in a defined ratio relative to each other;
- and
- (d) the one or more compounds are linked to the engineered decoration protein at a site on the engineered decoration protein other than the N-terminus or the C-terminus.
An isolated recombinant protein comprising the amino acid sequence of SEQ ID NO:
- 10 (gpD(S42C)).
21-36. (canceled)
Dependencies are inferred from the claim text.