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AssigneeIogen Energy Corporation
InventorsChristopher M. D. Hill, John J. Tomashek, James A. Lavigne, Sandra Mortimer, Reginald Storms, Adrian Tsang, Greg Butler, Justin Powlowski
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The present invention relates to a cellulose-degrading enzyme composition comprising one or more cellobiohydrolase and/or endoglucanase enzyme, and an effective amount of an isolated GH16 polypeptide, where the presence of the isolated GH16 polypeptide in the enzyme composition increases the rate or extent of degradation of a cellulosic substrate compared to an equivalent dosage of a corresponding cellulose-degrading enzyme composition lacking the at least one isolated GH16 polypeptide. The present invention also relates to a method for producing fermentable sugars from a cellulosic substrate using the above cellulose-degrading enzyme composition and to genetically modified microbes for produced the above cellulose-degrading enzyme composition.
1-21. (canceled)
A cellulose-degrading enzyme composition comprising, one or more cellobiohydrolase or endoglucanase enzymes, and an effective amount of at least one GH16 polypeptide, where the presence of the at least one GH16 polypeptide in the enzyme composition increases the rate or extent of degradation of a cellulosic substrate compared to an otherwise equivalent cellulose-degrading enzyme composition comprising the same one or more cellobiohydrolase or endoglucanase enzyme but lacking the at least one GH16 polypeptide, and wherein the at least one GH16 polypeptide comprises an amino acid sequence exhibiting at least 90% identity to SEQ ID NO:
A genetically modified microbe for producing a cellulose-degrading composition comprising, at least one polynucleotide encoding a cellobiohydrolase enzyme or an endoglucanase enzyme, and an polynucleotide encoding a GH16 polypeptide, wherein the GH16 polypeptide comprises an amino acid sequence exhibiting at least 90% identity to SEQ ID NO:
Dependencies are inferred from the claim text.