Probe for extraction of molecules of interest from a sample
AssigneeJp Scientific Limited
InventorsJanusz B. PAWLISZYN, German Augusto GOMEZ RIOS
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Abstract
A device is described for generating ionized molecules for analysis in a mass spectrometer. The device includes: a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer. The solid substrate may have at least two edges that meet at an angle from about 8° to about 180°. Mass spectrometry systems that include such a device are also described. Methods of analyzing a molecule previously extracted from a sample onto the device are also described.
Claims21
A device for generating ionized molecules for analysis in a mass spectrometer, the device comprising:
- a solid substrate having one or more edges and a coated area that is coated with an extraction phase comprising an extraction polymer.
A method for measuring or identifying one or more component of interest in a sample, said method comprising:
- positioning a fibre in the sample, the fibre being at least partially coated with an extraction phase for adsorbing said one or more component of interest from the sample, the extraction phase being positioned in the sample;
- adsorbing the one or more component of interest onto the extraction phase;
- removing the fibre from the sample;
- inserting the fibre into a mass spectrometer;
- exposing the fibre to a high voltage resulting in field desorption of the one or more component of interest directly from the extraction phase into the mass spectrometer for measurement or identification.
Dependencies are inferred from the claim text.