Systems and methods for analyzing biological pathways for the purpose of modeling drug effects, side effects, and interactions
AssigneeAdvaita Corporation
InventorAndrew Olson
Life of this patent
Estimating the term…
Abstract
Systems and methods for analyzing biological pathways are described. The techniques describe herein may enable the selection of candidate drugs to be prioritized. The systems and methods described herein provide visualizations for the impact of a drug on a gene signaling pathway. A visualization may be based on gene signaling pathway topology information and a determined gene expression level equivalent value for a drug.
Claims22
A method of modeling effects of a drug on a gene signaling pathway, the method comprising:
- receiving topology information associated with a gene signaling pathway;
- determining a gene expression level equivalent value for a drug;
- and
- calculating the impact of the drug on the gene signaling pathway based on the received topology information and the determined gene expression level equivalent value.
A method of modeling effects of a drug on a gene signaling pathway, the method comprising:
- receiving topology information associated with a gene signaling pathway;
- receiving differentially expressed gene data;
- determining a gene expression level equivalent value for a drug;
- and
- calculating an effective impact of the drug on the gene signaling pathway based on the received topology information, the received differentially expressed gene data, and the determined gene expression level equivalent value.
A method for enabling the analysis of effects of a drug on a gene signaling pathway, the method comprising:
- receiving a gene signaling pathway selection;
- receiving differentially expressed gene data;
- and
- providing a graphical user interface including a pathway diagram of the selected pathway, differentially expressed gene data, and a list of drugs known to act on the selected pathway.
Dependencies are inferred from the claim text.