Methodologies and Reagents for Detecting Fibrinolysis and Hyperfibrinolysis

A method for identifying an inhibitor of fibrinolysis that will achieve a beneficial response in a patient undergoing or likely to undergo fibrinolysis or hyperfibrinolysis, comprising:

• a) subjecting a first portion of a blood sample comprising reduced platelet function to viscoelastic analysis in the absence of an inhibitor of fibrinolysis to obtain the coagulation characteristic of the first portion at the time point;
• b) subjecting a second portion of the blood sample comprising reduced platelet function to viscoelastic analysis in the presence of first inhibitor of fibrinolysis to obtain a coagulation characteristic of the second portion at a time point;
• c) subjecting a third portion of a blood sample comprising reduced platelet function to viscoelastic analysis in the presence of first inhibitor of fibrinolysis to obtain a coagulation characteristic of the third portion at a time point;
• and
• d) comparing a first difference between the coagulation characteristic of the first portion and the coagulation characteristic of the second portion in the presence of the first inhibitor, and a second difference between the coagulation characteristic of the first portion and the coagulation characteristic of the third portion in the presence of the second inhibitor,
• wherein the patient will have beneficial result from treatment with the first inhibitor if the first difference is greater than the second difference, and the patient will have a beneficial result from treatment with the second inhibitor if the second inhibitor is greater than the first inhibitor.