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AssigneeIcahn School of Medicine at Mount Sinai
InventorsRoger Joseph Hajjar, Chang Won Kho, Ah Young Lee
Estimating the term…
Methods for treating cardiovascular disease, and in particular heart failure, are provided comprising administering a therapeutically effective amount of a modulator of SERCA2a post-translation modification such as SUMOylation or acetylation. Also provided are methods of treating cardiovascular disease by inhibiting SERCA2a degradation. Further provided are methods of diagnosing a propensity to develop heart failure comprising determining if a SERCA2a mutant is present or determining the level of expression of SUMO1 in cardiomyocytes. The disclosure also provides methods of screening for therapeutics that modulate the post-translational modification of SERCA2a, such as by modulating post-translational SUMOylation and/or acetylation.
1-15. (canceled)
A method of diagnosing a propensity to develop heart failure comprising determining the amino acid corresponding to a position selected from the group consisting of any of positions 479-482 and/or position 584-587 of human SERCA2a (SEQ ID NO:2).
A method of diagnosing a propensity to develop heart failure comprising determining the polynucleotide sequence encoding an amino acid corresponding to any of amino acids 479-482 or 584-587 of human SERCA2a (SEQ ID NO:1).
A method of diagnosing a propensity to develop heart failure comprising determining the level of expression of SUMO1 in a cardiomyocyte of a subject and comparing that level to the level of expression of SUMO1 in a cardiomyocyte of a healthy control, wherein reduced expression of SUMO1 relative to the control is indicative of a propensity to develop cardiac failure.
(canceled)
Dependencies are inferred from the claim text.