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AssigneeUniversitaet des Saarlandes
InventorsMichael Pfreundschuh, Klaus-Dieter Preuss, Lorenz Thurner
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The present invention provides for means and method for the detection and/or the quantification of anti-progranulin-autoantibodies in a biological sample of a subject. The present invention also provides for means and method for the detection and/or the quantification of hyper-phosphorylated progranulin in a biological sample of a subject. The present invention further provides for means and methods for the detection of an aberrant conversion pathway of progranulin into granulines in a biological sample of a subject. In fact, the presence of anti-progranulin-autoantibodies and/or hyper-phosphorylated progranulin and/or an aberrant conversion pathway may be indicative that the subject may be suffering from an autoimmune disorder.
An in vitro method for detection of anti-progranulin-autoantibodies in a biological sample comprising use of progranulin or an antigenic progranulin peptide/fragment or variant thereof.
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11-38. (canceled)
A method for treating an immune disorder in a subject, comprising administering an immune modulator to a subject, said subject having anti-progranulin autoantibodies based on diagnosis, wherein administering ameliorates, prevents, or treats the autoimmune disorder in the subject.
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45-55. (canceled)
An in vitro method for detection of hyper-phosphorylated progranulin or an antigenic hyper-phosphorylated progranulin peptide/fragment thereof in a biological sample comprising steps of:
Dependencies are inferred from the claim text.