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US 2015/0316531 A1Published application
Automated Analyzer and Automated Analysis Method
AssigneeHitachi High-Technologies Corporation
InventorsShinji TARUMI, Chie YABUTANI, Akihisa MAKINO, Chihiro MANRI, Satoshi MITSUYAMA
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Abstract
Provided is technology for blood clotting reactions capable of analyzing a blood clotting reaction with a high degree of precision, by precisely detecting and removing noise, regardless of the location where the noise is generated in the light intensity data. This automated analyzer approximates, with an approximation curve, time series data for transmitted light intensity or scattered light intensity of light emitted onto a sample, and, in this process, removes abnormal data points that deviate from the approximation curve (see FIG. 2).
Claims13
An automated analysis device that analyzes a blood clotting reaction comprising;
- a reaction container for mixing a sample with a reagent to cause a reaction;
- a measuring unit that irradiates light onto a reaction solution in the reaction container and that measures a scattered light intensity or a transmitted light intensity;
- a controller that processes chronological light intensity data measured by the measuring unit;
- a storage unit that stores one or more of approximation, functions approximating a chronological variation of the light intensity data;
- and
- an output unit that outputs a processed result of the controller,
- wherein the controller selects one of the approximation functions stored in the storage unit,
- wherein the controller performs:
- a first process calculating an approximated curve representing a chronological variation of the light, intensity data using the selected approximation function;
- a second process detecting, using the approximated curve, an abnormal data point included in the light intensity data;
- and a third process removing the abnormal data point from the light intensity data,
- wherein the controller analyses the blood clotting reaction, using at least one of the light intensity data and the approximated curve,
- and wherein when detecting the abnormal data point in the third process, the controller detects, as the abnormal data point, only one of a data point in the light intensity data having a light intensity value larger than that of the approximated curve and a data point in the light intensity data having a light intensity value smaller than that of the approximated curve.
10 more elements
An automated analysis device that analyzes a blood clotting reaction comprising;
- a reaction container for mixing a sample with a reagent to cause a reaction;
- a measuring unit that irradiates light onto a reaction solution in the reaction container and that measures a scattered light intensity or a transmitted light intensity;
- a controller that processes chronological light intensity data measured by the measuring unit;
- a storage unit that stores one or more of approximation functions approximating a chronological variation of the light intensity data;
- and
- an output unit that outputs a processed result of the controller,
- wherein the controller selects one of the approximation functions stored in the storage unit,
- wherein the controller performs:
- a first process calculating art approximated curve representing a chronological variation of the light intensity data using the selected approximation function ;
- a second process detecting, using the approximated curve, an abnormal data point included in the light intensity data;
- and a third process removing the abnormal data point from the light intensity data,
- wherein the controller repeats the first process, the second process, and the third process for at least one or more times,
- and wherein the controller analyzes the blood clotting reaction using at least one of the light intensity data and the approximated curve with a state satisfying a predetermined convergence condition.
10 more elements
An automated analysis method for analyzing a blood clotting reaction comprising:
- a measuring step of irradiating light onto a reaction solution in a reaction container for mixing a sample with a reagent to cause a reaction and of measuring a scattered light intensity or a transmitted light intensity;
- a control step of processing chronological light intensity data measured in the measuring step;
- and
- an output step of outputting a processed result in the control step,
- wherein the control step includes a step of selecting and reading an approximation function approximating a chronological variation of the light intensity data from a storage unit that stores one or more of the approximation functions,
- wherein the control step includes a step of performing:
- a first process calculating an approximated curve representing a chronological variation of the light intensity data using the selected approximation function;
- a second process detecting, using the approximated curve, an abnormal data point included in the light intensity data;
- and a third process removing the abnormal data point from the light intensity data,
- wherein the control step includes a step of analyzing the blood clotting reaction using at least one of the light intensity data and the approximated curve,
- and wherein when detecting the abnormal data point in the third process, only one of a data point in the light intensity data having a light, intensity value larger than that of the approximated curve and a data point in the light intensity data having a light intensity value smaller than that of the approximated curve is detected as the abnormal data point.
8 more elements
Dependencies are inferred from the claim text.