Correction of Time of Flight MS ADC Data on Push by Push Basis
AssigneeMicromass UK Limited
InventorsMartin Raymond Green, Steven Derek Pringle, Jason Lee Wildgoose, David J. Langridge
Life of this patent
Estimating the term…
Abstract
A method of mass spectrometry is disclosed comprising pulsing ions into a time of flight region and detecting the ions using an ion detector. The signal output from the ion detector is digitised to produce a digitised signal. The peak area A1 and arrival time T1 of the ion peak are determined and a degree to which the ion peak suffers from saturation is also determined. A corrected area A′1 of the ion peak is then determined based upon the degree to which the ion peak was determined to suffer from saturation.
Claims22
A method of mass spectrometry comprising:
- pulsing first ions into a time of flight region and detecting said first ions using an ion detector;
- digitising a first signal output from said ion detector to produce a first digitised signal, determining a first area A1 and a first ion arrival time T1 of a first ion peak in said first digitised signal, determining a degree to which said first ion peak suffers from saturation and determining a first corrected area A′1 of said first ion peak based upon the degree to which said first ion peak was determined to suffer from saturation;
- pulsing second ions into said time of flight region and detecting said second ions using said ion detector;
- and
- digitising a second signal output from said ion detector to produce a second digitised signal, determining a second area A2 and a second ion arrival time T2 of a second ion peak in said second digitised signal, determining a degree to which said second ion peak suffers from saturation and determining a second corrected area A′2 of said second ion peak based upon the degree to which said second ion peak was determined to suffer from saturation.
20-32. (canceled)
A mass spectrometer comprising:
- a time of flight region and an ion detector;
- and
- a control system arranged and adapted:
- (i) to pulse first ions into said time of flight region and to detect said first ions using said ion detector;
- (ii) to digitise a first signal output from said ion detector to produce a first digitised signal, to determine a first area A1 and a first ion arrival time T1 of a first ion peak in said first digitised signal, to determine a degree to which said first ion peak suffers from saturation and to determine a first corrected area A′1 of said first ion peak based upon the degree to which said first ion peak was determined to suffer from saturation;
- (iii) to pulse second ions into said time of flight region and to detect said second ions using said ion detector;
- and
- (iv) to digitise a second signal output from said ion detector to produce a second digitised signal, to determine a second area A2 and a second ion arrival time T2 of a second ion peak in said second digitised signal, to determine a degree to which said second ion peak suffers from saturation and to determine a second corrected area A′2 of said second ion peak based upon the degree to which said second ion peak was determined to suffer from saturation.
34-78. (canceled)
Dependencies are inferred from the claim text.