Identification of the dcps gene on 11q24.2, which encodes the human decapping enzyme scavenger, in non-syndromic autosomal recessive mental retardation, diagnostic probes thereof and methods of identifying subjects with same

A Decapping Enzyme Scavenger nucleotide sequence associated with Non-Syndromic Autosomal Recessive Mental Retardation, the nucleotide sequence comprising:

• a) at least 7 consecutive nucleotides of SEQ ID NO:
• 2 and comprising “A” at position 51, or a sequence complementary thereto;
• b) at least 7 consecutive nucleotides of SEQ ID NO:
• 4 and further comprising ATAAAGGTTTCTGGCTGGAATGTCCTGATCTCTGGCCACCCTGCT defined by SEQ ID NO:
• 13, or a fragment thereof, or a nucleotide sequence that is complementary thereto;
• c) at least 7 consecutive nucleotides of SEQ ID NO:
• 8 and comprising T at position 271, or a sequence complementary thereto, or;
• d) at least 7 consecutive nucleotides of SEQ ID NO:
• 12 and further comprising T at position 947, or a sequence complementary thereto;
• e) at least 80% identity to the nucleotide sequence defined in any one of a)-d).