One-pot fermentation process for simvastatin production

Abstract

Simvastatin is a drug used in treatment of hypercholesterolemia because of its inhibitory activities towards cholesterol biosynthesis. The technology described herein is a novel method of biosynthesizing Simvastatin directly from an engineered microbial host (such as Saccharomyces cerevisiae) using an engineered biosynthetic pathway. The identification and engineering of Aspergillus terreus biosynthetic pathways opens up new metabolic engineering opportunities for statin production from organisms such as yeast. Using this technology, Simvastatin can be obtained by feeding a simple synthetic building block to fermented culture. Such methods provide a cost-effective way of obtaining Simvastatin including, for example, one-pot fermentation processes.

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