Production method for cyclopentanone derivative, intermediate compound, and production method for intermediate compound
AssigneeKureha Corporation
InventorsShigeyuki KIKUMOTO, Takashi SHIMOKAWARA
Life of this patent
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Abstract
A method for producing a cyclopentanone derivative represented by general formula (III) below, wherein a cyclopentanone derivative represented by general formula (III) below can be produced with higher yield since the method comprises a step in which a compound represented by general formula (II) below is obtained by reacting a compound represented by general formula (I) below with an acid.
Claims10
A production method for a cyclopentanone derivative represented by general formula (III) below:
- in formula (III), X is a halogen atom, an alkyl group having from 1 to 4 carbons, a haloalkyl group having from 1 to 4 carbons, an alkoxy group having from 1 to 4 carbons, a haloalkoxy group having from 1 to 4 carbons, a phenyl group, a cyano group, or a nitro group;
- m is an integer from 0 to 5;
- a plurality of X moieties may be the same or different when m is 2 or greater;
- G1 and G2 each represents a protecting group that dissociates under acidic conditions, G1 and G2 may be the same or different, and G1 and G2 may bond with one another to form a ring;
- the method comprising a step of obtaining a compound represented by general formula (II) below by reacting a compound represented by general formula (I) below with an acid:
- in formula (I), X and m are each the same as X and m in formula (III), and R is an alkyl group having from 1 to 4 carbons;
- and
- in formula (II), X and m are each the same as X and m in formula (III).
A production method for a compound represented by general formula (II) below:
- in formula (II), X is a halogen atom, an alkyl group having from 1 to 4 carbons, a haloalkyl group having from 1 to 4 carbons, an alkoxy group having from 1 to 4 carbons, a haloalkoxy group having from 1 to 4 carbons, a phenyl group, a cyano group, or a nitro group;
- m is an integer from 0 to 5;
- and a plurality of X moieties may be the same or different when m is 2 or greater;
- and
- wherein a compound represented by general formula (I) below is reacted with an acid:
- in formula (I), X and m are each the same as X and m in formula (II), and R is an alkyl group having from 1 to 4 carbons.
A production method for a cyclopentanone derivative represented by general formula (III) below:
- in formula (III), X is a halogen atom, an alkyl group having from 1 to 4 carbons, a haloalkyl group having from 1 to 4 carbons, an alkoxy group having from 1 to 4 carbons, a haloalkoxy group having from 1 to 4 carbons, a phenyl group, a cyano group, or a nitro group;
- m is an integer from 0 to 5;
- a plurality of X moieties may be the same or different when m is 2 or greater;
- G1 and G2 each represents a protecting group that dissociates under acidic conditions, G1 and G2 may be the same or different, and G1 and G2 may bond with one another to form a ring;
- a hydroxy group of a compound represented by general formula (II) below being protected by a protecting group that dissociates under acidic conditions:
- in formula (II), X and m are each the same as X and m in formula (III).
A compound represented by general formula (II) below:
- in formula (II), X is a halogen atom, an alkyl group having from 1 to 4 carbons, a haloalkyl group having from 1 to 4 carbons, an alkoxy group having from 1 to 4 carbons, a haloalkoxy group having from 1 to 4 carbons, a phenyl group, a cyano group, or a nitro group;
- m is an integer from 0 to 5;
- and a plurality of X moieties may be the same or different when m is 2 or greater.
Dependencies are inferred from the claim text.