Method for predicting gene cluster including secondary metabolism-related genes, prediction program, and prediction device

A program for predicting a gene cluster including secondary metabolism-related genes that allows a computer equipped with an input unit, a central processing unit, and a storage unit to execute:

• a step in which the central processing unit is allowed to execute homology search of genes included in nucleotide sequence information of at least a pair of genomes mutually to identify homologous gene combinations in the nucleotide sequence information of genomes and orthologous gene combinations in the homologous gene combinations;
• a step in which the central processing unit is allowed to identify a region of the gene arrangement of which is conserved in the nucleotide sequence information of other genomes on the basis of the results of homology search as a gene cluster;
• and
• a step in which the central processing unit is allowed to identify a synteny-like region in the gene cluster identified in the above step on the basis of the presence of orthologous genes and evaluate whether or not the gene cluster includes secondary metabolism-related genes on the basis of the rate of the synteny-like region in the gene cluster.

A prediction device for a gene cluster including secondary metabolism-related genes equipped with an input unit, a central processing unit, and a storage unit,

• the device comprising:
• a means for homology search by which the central processing unit is allowed to execute homology search of genes included in nucleotide sequence information of at least a pair of genomes mutually to identify homologous gene combinations in the nucleotide sequence information of genomes and orthologous gene combinations in the homologous gene combinations;
• a means for gene cluster identification by which the central processing unit is allowed to identify a region of the gene arrangement of which is conserved in the nucleotide sequence information of other genomes on the basis of the results of homology search as a gene cluster;
• and
• a means for evaluation by which the central processing unit is allowed to identify a synteny-like region in the gene cluster identified by the means for gene cluster identification on the basis of the presence of orthologous genes found as a result of the homology search and evaluate whether or not the gene cluster includes secondary metabolism-related genes on the basis of the rate of the synteny-like region in the gene cluster.