System and method for processing genotype information relating to pain perception

A method for utilizing prognostic information about pain perception, comprising:

• receiving information, including DNA information, associated with a human subject,
• wherein the received information indicates that the human subject is characterized by at least two demographic phenotypes, the subject has a subject genotype that includes a COMT haplotype diploid, the subject genotype includes at least two SNP diploids, or a combination thereof,
• wherein the COMT haplotype diploid is a combination of two COMT haplotypes selected from an LPS haplotype, an APS haplotype, a HPS haplotype or a combination thereof in the COMT gene,
• wherein each of the at least two SNP diploids is a combination of two SNP alleles associated with one SNP location, the SNP alleles selected from DRD1-ANC, DRD1-HET, and DRD1-NONA in the DRD1 gene, COMT(2)-ANC, COMT(2)-HET, and COMT(2)-NONA in the COMT gene, SLC6A4*-ANC, SLC6A4*-HET, and SLC6A4*-NONA in the SLC6A4 gene, OPRK1-ANC, OPRK1-HET, and OPRK1-NONA in the OPRK1 gene, DRD2-ANC, DRD2-HET, and DRD2-NONA in the DRD2 gene, MTHFR-ANC, MTHFR-HET, and MTHFR-NONA in the MTHFR gene, SLC6A4-ANC, SLC6A4-HET, and SLC6A4-NONA in the SLC6A4 gene, HTR2A-ANC, HTR2A-HET, and HTR2A-NONA in the HTR2A gene, DBH-ANC, DBH-HET, and DBH-NONA in the DBH gene, GABRG2-ANC, GABRG2-HET, and GABRG2-NONA in the GABRG2 gene, OPRM1-ANC, OPRM1-HET, and OPRM1-NONA in the OPRM1 gene, SLC6A3-ANC, SLC6A3-HET, and SLC6A3-NONA in the SLC6A3 gene,
• wherein the at least two demographic phenotypes are selected from race, age, gender, depression and/or other mental health demographic phenotypes;
• processing the received information utilizing a processor;
• and
• determining a therapy for the human subject based, at least in part, on the processed information.

A method for performing an assay, comprising:

• providing a sample of genetic material of a human subject;
• and
• determining DNA information from the sample, the DNA information including whether a subject genotype of the subject includes a COMT haplotype diploid, the subject genotype of the subject includes at least two SNP diploids, or a combination thereof, by detecting, utilizing a detection technology and the sample, a presence or absence of the COMT haplotype diploid and/or the at least two SNP diploids in the subject genotype,
• wherein the COMT haplotype diploid is a combination of two COMT haplotypes selected from LPS haplotype, APS haplotype, HPS haplotype or a combination thereof in the COMT gene,
• wherein each of the at least two SNP diploids is a combination of two SNP alleles associated with one SNP location, the SNP alleles selected from
• DRD1-ANC, DRD1-HET, and DRD1-NONA in the DRD1 gene, COMT(2)-ANC, COMT(2)-HET, and COMT(2)-NONA in the COMT gene, SLC6A4*-ANC, SLC6A4*-HET, and SLC6A4*-NONA in the SLC6A4 gene, OPRK1-ANC, OPRK1-HET, and OPRK1-NONA in the OPRK1 gene, DRD2-ANC, DRD2-HET, and DRD2-NONA in the DRD2 gene, MTHFR-ANC, MTHFR-HET, and MTHFR-NONA in the MTHFR gene, SLC6A4-ANC, SLC6A4-HET, and SLC6A4-NONA in the SLC6A4 gene, 5-HTR2A-ANC, 5-HTR2A-HET, and 5-HTR2A-NONA in the 5-HTR2A gene, DBH-ANC, DBH-HET, and DBH-NONA in the DBH gene, GABRG2-ANC, GABRG2-HET, and GABRG2-NONA in the GABRG2 gene, OPRM1-ANC, OPRM1-HET, and OPRM1-NONA in the OPRM1 gene, SLC6A3-ANC, SLC6A3-HET, and SLC6A3-NONA in the SLC6A3 gene.