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US 2015/0309210 A1Published application
Hydrophilized carbosiloxane vinylic monomers
AssigneeNovartis AG
InventorsJinyu Huang, Frank Chang
Life of this patent
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Abstract
The invention provides a hydrophilized carbosiloxane vinylic monomer which comprises (1) a poly(carbosiloxane) segment, (2) one sole ethylenically unsaturated group, and (3) at least one terminal or pendant group which is a hydrophilic group or hydrophilic polymer chain. The present invention is also related to a polymer, an actinically-crosslinkable silicone-containing prepolymer, a silicone hydrogel polymeric material, or a silicone hydrogel contact lens, which comprises monomeric units derived from a hydrophilized carbosiloxane vinylic monomer of the invention.
Claims17
A carbosiloxane vinylic monomer of formula (I)
- in which
- e1, e2, e3, and e4 independent of one another are an integer of 0 or 1, provided that at least one of e1, e2, e3, and e4 is an integer of 1 and (e1+e2+e3)≦2,
- n1 is an integer of 2 or 3,
- n2 is an integer of from 2 to 100,
- E is C1-C6 alkyl radical or
- in which R7, R8 or R9 independent of one another is a C1-C6 alkyl,
- G1, G2, G3, and G4 independent of one another are a hydrophilic group or a hydrophilic polymer chain,
- L1 is a covalent bond or a C1-C6 alkyl diradical,
- L2 is a C1-C6 alkyl diradical,
- L3 is a C1-C6 alkyl diradical if e4 is an integer of 1 or a covalent bond if e4 is an integer of 0,
- R1, R2, R3, R4, R5, and R6 independent of one another are a C1-C6 alkyl radical,
- Q is the ethylenically unsaturated group,
- T1, T2, and T3 independent of one another are a C1-C6 alkyl tri-radical
- X1, X2, and X3 independent of one another is —O—, —NRo—, —CO—NRo—, —NRo—CO—, —NRo—CO—NH—, —NH—CO—NRo—, —O—CO—NH—, —NH—CO—O—, —O—CO—, —CO—O—, —NRo—CO—NH-L4-NH—CO—NRo—, —O—CO—NH-L4-NH—CO—O—, —NRo—CO—NH-L4-NH—CO—O—, or —O—CO—NH-L4-NH—CO—NRo— in which Ro is H or C1-C10 alkyl and L4 is an alkyl diradical, a cycloalkyl diradical, an alkylcycloalkyl diradical, an alkylaryl diradical, or an aryl diradical with up to 40 carbon atoms.
11 more elements
Dependencies are inferred from the claim text.