Giant Liposome Array for High-throughput Lipid-Interaction Screening
AssigneeEuropean Molecular Biology Laboratory (EMBL)
InventorsAnne-Claude GAVIN, Jan ELLENBERG, Antoine-Emmanuel SALIBA, Ivana VONKOVA
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Abstract
The present invention relates to liposome arrays, devices comprising said liposome arrays, the uses of said liposome arrays as well as methods of producing said liposome arrays.
Claims45
A liposome array comprising a carrier layer, layer of substrate on the surface of the carrier layer and at least two separate areas of liposomes on its surface.
A liposome array comprising a carrier layer, a non-continuous substrate on the surface of the carrier layer and one or more liposomes in contact with the non-continuous substrate.
A method of producing liposomes of a predetermined size comprising the steps of:
- (a) forming a substrate of a thickness between 1 nm to 2 μm;
- and
- (b) applying a lipid or a lipid composition to at least one surface area of the substrate.
A method of aligning liposomes comprising the steps of:
- (a) forming a non-continuous substrate;
- and
- (b) applying a lipid and/or a lipid composition to at least one surface area of the substrate;
- and
- (c) forming liposomes from the lipid and/or the lipid composition of step (b).
Dependencies are inferred from the claim text.