Acute kidney injury
OwnerFrank DIETERLE, Holger HOEFLINGinventors
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Abstract
The present invention relates to a method of predicting the severity of acute kidney injury following cardiac surgery.
Claims17
A method of assessing the severity of acute kidney injury (AKI) injury in a subject following cardiac surgery, comprising:
- measuring one or more markers from Table 1 and/or Table 2 in a biological sample obtained from the subject within 24 hours following cardiac surgery;
- generating a risk score based on the measured level of one or more of the biomarkers from Table 1, wherein if the risk score exceeds a predefined cutoff, the subject is determined to be at risk of developing RIFLE I/F;
- and
- optionally, if the subject is not determined to be at risk of developing RIFLE I/F, further generating a risk score based on the measured level of one or more of the biomarkers selected from Table 2, wherein if the risk score exceeds a predefined cutoff, the subject is determined to be at risk of developing RIFLE R or if the risk score is below the predefined cutoff the subject is determined not to be at risk of developing AKI.
(canceled)
A method of assessing the severity of acute kidney injury (AKI) injury in a subject following cardiac surgery, comprising:
- measuring at least two of the following biomarkers selected from the group consisting of IL-18, Cystatin C, NGAL, TFF3, Clusterin, and A1-Microglobulin in a biological sample obtained from the subject within 24 hours following cardiac surgery;
- and
- generating a risk score based on the measured level of the at least two biomarkers wherein the risk score is indicative if the subject is at risk of developing RIFLE I/F
(canceled)
A method of diagnosing or predicting development of acute kidney injury (AKI) in a subject following cardiac surgery, comprising measuring at least four of the following biomarkers selected from IL-18, Cystatin C, NGAL, TFF3, Clusterin, B2-microglobulin and A1-Microglobulin in a biological sample obtained from the subject within 24 hours following cardiac surgery;
- wherein the levels are indicative of AKI or are predictive of the development of AKI.
-14. (canceled)
-19. (canceled)
Dependencies are inferred from the claim text.