Treatment-induced damage to the tumor micro-environment promotes cancer therapy resistance through extracellular proteins
AssigneeFred Hutchinson Cancer Research Center
InventorsPeter S. Nelson, Yu Sun
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Abstract
The present disclosure provides methods for determining the effectiveness of a cancer therapy, as well as methods for increasing the effectiveness of that therapy and determining a prognosis for a patient receiving that therapy.
Claims18
A method for enhancing the effectiveness of a cancer therapeutic by administering an agent that inhibits the activity of a gene encoding an extracellular protein that is increased subsequent to treatment of a patient with a genotoxic agent.
A method for determining the effectiveness of a cancer therapeutic in a patient, comprising:
- i) obtaining a sample of a tumor microenvironment from the patient;
- ii) measuring the level of expression of at least one extracellular protein in the sample;
- and
- iii) assessing whether the level of the at least one extracellular protein is increased as compared with a control sample;
- wherein a decreased or unchanged level of the at least one extracellular protein is indicative of effectiveness of the cancer therapeutic and wherein an increased level of the at least one extracellular protein is indicative of a decreased effectiveness of the cancer therapeutic.
A method for determining a prognosis in a cancer patient treated with a cancer therapeutic;
- comprising
- (i) obtaining a sample of a tumor microenvironment from the patient;
- (ii) measuring the level of expression of at least one extracellular protein in the sample;
- and
- (iii) assessing whether the level of the at least one extracellular protein is increased as compared with a control sample;
- wherein a decreased or unchanged level of expression of the at least one extracellular protein is determinant of a more favorable prognosis and wherein an increase in the expression of the at least one extracellular protein is determinant of a less favorable prognosis.
Dependencies are inferred from the claim text.