Antibody Cocktail Systems and Methods for Classification of Histologic Subtypes in Lung Cancer
AssigneeBiocare Medical, LLC
InventorDavid Tacha
Life of this patent
Estimating the term…
Abstract
The present invention relates to compositions and detection systems of antibodies or fragments thereof, wherein at least two antibodies or fragments thereof binds specifically to squamous cell carcinoma (SCC) and/or adenocarcinoma (ADC). Methods for using the antibodies in diagnosis, prognosis, and assessing efficacy of treatment is further included as well as kits including such compositions and detection systems.
Claims24
A lung cancer detection system comprising:
- at least two primary antibodies or fragments thereof,
- wherein at least one primary antibody or fragment thereof specifically binds to squamous cell carcinoma (SCC);
- and
- wherein at least one primary antibody or fragment thereof specifically binds to adenocarcinoma (ADC).
A lung cancer detection system comprising at least two primary antibodies or fragments thereof, wherein at least two primary antibodies each specifically binds to squamous cell carcinoma (SCC).
A lung cancer detection system comprising at least two primary antibodies or fragments thereof, wherein at least two primary antibodies each specifically binds to adenocarcinoma (ADC).
6-7. (canceled)
A lung cancer detection system comprising a primary antibody combination selected from the group consisting of:
- anti-DSG-3 antibody or fragment thereof, anti-CK5 antibody or fragment thereof, and anti-Napsin A antibody or fragment thereof;
- anti-p40 antibody or fragment thereof, and anti-TTF-1 antibody or fragment thereof;
- anti-DSG-3 antibody or fragment thereof, anti-p40 antibody or fragment thereof, and anti-Napsin A antibody or fragment thereof;
- anti-DSG-3 antibody or fragment thereof, and anti-p40 antibody or fragment thereof;
- anti-p40 antibody or fragment thereof, and anti-CK5 antibody or fragment thereof;
- anti-CK7 antibody or fragment thereof, and anti-TRIM29 antibody or fragment thereof;
- anti-DSG-3 antibody or fragment thereof, anti-CK5 antibody or fragment thereof, anti-Napsin A antibody or fragment thereof, and anti-TTF-1 antibody or fragment thereof;
- anti-DSG-3 antibody or fragment thereof, anti-CK5 antibody or fragment thereof, anti-p40 antibody or fragment thereof, anti-Napsin A antibody or fragment thereof, and anti-TTF-1 antibody or fragment thereof;
- anti-DSG-3 antibody or fragment thereof, anti-CK5 antibody or fragment thereof, and anti-p40 antibody or fragment thereof;
- anti-DSG-3 mouse antibody or fragment thereof, anti-CK5 mouse antibody or fragment thereof, anti-Napsin A rabbit antibody or fragment thereof;
- anti-p40 rabbit antibody or fragment thereof, and anti-TTF-1 mouse antibody or fragment thereof;
- anti-DSG-3 mouse antibody or fragment thereof, anti-p40 mouse antibody or fragment thereof, and anti-Napsin A rabbit antibody or fragment thereof;
- anti-DSG-3 mouse antibody or fragment thereof, and anti-p40 mouse antibody or fragment thereof;
- anti-p40 mouse antibody or fragment thereof, and anti-CK5 rabbit antibody or fragment thereof;
- anti-TRIM29 rabbit antibody or fragment thereof, and anti-CK7 mouse antibody or fragment thereof;
- anti-DSG-3 mouse antibody or fragment thereof, anti-CK5 mouse antibody or fragment thereof, anti-Napsin A rabbit antibody or fragment thereof, and anti-TTF-1 mouse antibody or fragment thereof;
- anti-DSG-3 mouse antibody or fragment thereof, anti-CK5 mouse antibody or fragment thereof, anti-p40 rabbit antibody or fragment thereof, anti-Napsin A rabbit antibody or fragment thereof, and anti-TTF-1 mouse antibody or fragment thereof;
- anti-DSG-3 mouse antibody or fragment thereof, anti-CK5 mouse antibody or fragment thereof, and anti-p40 rabbit antibody or fragment thereof;
- and
- anti-DSG-3 mouse antibody or fragment thereof, and anti-p40 rabbit antibody or fragment thereof.
12-13. (canceled)
(canceled)
26-54. (canceled)
Dependencies are inferred from the claim text.