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AssigneeIndustry-Academic Cooperation Foundation, Yonsei University
InventorsKang-Yell CHOI, Woo-Jeong JEONG
Estimating the term…
Methods of diagnosing cancer and screening for an anti-cancer drug using Ras are provided. Ras has a very significant role as a prevalent proto-oncogene which has abnormalities in most forms of cancer, and thus the methods of diagnosing cancer and screening for an anti-cancer drug using Ras may be applied to various forms of cancer. The generation of various forms of cancer in the early stages may be determined by examining whether or not phosphorylation of Ras occurs at Thr-144 and Thr-148 sites. By such a mechanism, an anti-cancer drug having excellent anti-cancer effectiveness may be screened, or the effectiveness of the anti-cancer drug may be tested.
A method of analyzing the level of Ras protein, comprising examining whether or not phosphorylation of Ras occurs at Thr-144 and Thr-148 sites of Ras.
A composition for diagnosing cancer, comprising an antibody specifically recognizing phosphate groups of Thr-144 and Thr-148 of Ras.
A kit for diagnosing cancer, comprising an antibody specifically recognizing phosphate groups of Thr-144 and Thr-148 of Ras.
A method of screening for an anti-cancer drug, comprising contacting Ras with a candidate material, examining whether or not phosphorylation of Ras occurs at Thr-144 and Thr-148 sites of Ras, and determining whether the candidate material inhibits or stimulates the phosphorylation.
A method of screening for an anti-cancer drug, comprising treating a cell or an animal, excluding humans, with a candidate material;
A method of verifying the effectiveness of an anti-cancer drug, comprising treating an animal, excluding humans, with an anti-cancer drug;
An antibody specifically recognizing phosphate groups of Thr-144 and Thr-148 of Ras.
Dependencies are inferred from the claim text.