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AssigneeHitachi High-Technologies Corporation
InventorsToshiro Saito, Kenta Imai, Kyoko Imai, Kazumichi Imai, Itaru Yanagi, Yoshimitsu Yanagawa, Masahiko Ando, Naoshi Itabashi
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The present invention is intended to provide a method and a device for detecting a biomolecule with high sensitivity and high throughput over a wide dynamic range without requiring concentration adjustments of a sample in advance. The present invention specifically binds charge carriers to a detection target biomolecule, and detects the detection target biomolecule one by one by measuring a current change that occurs as the conjugate of the biomolecule and the charge carriers passes through a micropore. High-throughput detection of a biomolecule sample is possible with an array of detectors.
A biomolecule detection method comprising:
A biomolecule detection device comprising a device having a field-effect transistor and a through pore, wherein the device is provided as means for individually measuring an amount of charge of a conjugate generated through a reaction between a detection target biomolecule, a charge carrier having a surface with a first antibody against the biomolecule, and a charge carrier having a surface with a second antibody against the biomolecule.
An analysis device for measuring the abundance of a conjugate of a target molecule held to charge carriers,
Dependencies are inferred from the claim text.