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AssigneeRhode Island Board of Education, State of Rhode Island and Providence Plantations
InventorsYing Sun, Charles Scouten
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A method and an apparatus are disclosed for measuring the electrical properties of biological cells. The method involves a switching excitation with a sinusoidally amplitude-modulated current coupled with a real-time estimation algorithm for extracting a phase-shifted sinusoidal voltage output. The algorithm uses a unique time-domain formulation that provides accurate and continuous measurements with a high temporal resolution. The invention is suitable for measuring small signals under noisy conditions such as the membrane resistance and capacitance of a living cell accessed via a microelectrode. The resulting apparatus achieves a similar effect of a lock-in amplifier for suppressing noise but with a different approach. The invention also has the advantage that the input and the output can be decoupled by time-multiplexing on a single electrode.
A method for measuring the electrical properties of a measurand via a single port comprising the steps of
An apparatus for measuring the electrical properties of a measurand via a single port comprising:
Dependencies are inferred from the claim text.