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AssigneeFoss Analytical A/S
InventorsChrister BISGAARD, Thomas LAURELL, Carl GRENVALL, Christian ANTFOLK
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A microfluidic impedance flow cytometer (‘MIC’) device (2) comprises a substrate (4) in which is formed at least one flow channel (6) for leading through a particle (22) containing fluidic sample. The flow channel (6) is formed with a focusing zone (12) and a measurement zone (14) located downstream of the focusing zone (12) in the direction of through flow and provided with an electrode arrangement (18) for characterising particles (22) in the flowing fluidic sample by means of electrical impedance wherein an acoustophoretic particle focusing arrangement (20) is provided in acoustic coupling to the flow channel (6) in the focusing zone (12) to induce acoustic forces in fluid in the flow channel (6) so as to effect a lateral and/or vertical focusing of particles before flowing to the measurement zone (14).
A microfluidic impedance flow cytometer (‘MIC’) device (2) comprising a substrate (4) in which is formed at least one flow channel (6) for leading through a particle (22) containing fluidic sample, the flow channel (6) comprising a focusing zone (12) and a measurement zone (14) located downstream of the focusing zone (12) and provided with an electrode arrangement (18) for characterising particles (22) in the flowing fluidic sample by means of electrical impedance characterised in that an acoustophoretic particle focusing arrangement (20) is provided in acoustic coupling to the flow channel (6) in the focusing zone (12).
A MIC device as claimed in any preceding claim characterised in that the electrode arrangement (18) comprises a plurality of planar electrodes (18a . . . g) provided across on side of a measurement channel (16) of the measurement zone (14).
A method for performing flow cytometry in a microfluidic impedance flow cytometer (MIC) having a flow channel formed in a substrate, comprising the steps of:
Dependencies are inferred from the claim text.