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AssigneeContipro Biotech S.R.O.
InventorsJolana Scudlova, Jiri Betak, Lucie Wolfova, Radovan Buffa, Klara Slezingrova, Pavel Klein, Ilona Matejkova, Martin Bobek, Tomas Pitucha, Vladimir Velebny, Romana Sulakova
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The invention relates to the biodegradable fibres which are based on hydrophobic derivatives of hylauronan, specifically on the base of the hyaluronan derivative C11-C18-acylated on hydroxyl groups of hyaluronic acid, and use thereof. Further the invention relates to the preparation of these fibres which is performed with the use of the wet spinning method in a coagulation bath comprising water solution of organic acid, with the production of continuous monofiles which can be thereafter processed to threads and further to textiles, knitted textiles, or nonwoven textiles. These textiles, knitted textiles or nonwoven textiles can be used for example for the production of implantable surgical material for human and veterinary medicine.
A method of a preparation of fibres based on the hyaluronan derivative C11-C18-acylated on hydroxyl groups of hyaluronic acid characterized in that it is prepared a spinning solution comprising an acylated derivative of Hyaluronan of the concentration in the range of 0.01% by weight to 15% by weight in the mixture of water and 2-propanol, where water content is in a range of 30% by volume to 90% by volume, a content of 2-propanol is 10% by volume to 70% by volume, then the spinning solution is introduced to the coagulation bath comprising water solution of organic acid or its salts of alkali metals, or alkaline earth metals, wherein the acid is selected from the group comprising lactic, tartaric, citric, malic, ascorbic, oxalic acid or a combination thereof, to form fibres which are then washed with alcohol and dried.
A fibre based on the hyaluronan derivative C11-C18-acylated on hydroxyl groups of hyaluronic acid characterized in that its diameter is 50 to 300 μm and its tensile strength is in the range of 0.3 to 1 cN/dtext, and its elongation is in the range of 10 to 40%.
Dependencies are inferred from the claim text.