Manufacturing method for a butanediol, fabrication method for a microbe for manufacturing a butanediol, and microbe
AssigneeShowa Denko K.K.
InventorsHirobumi AOKI, Yuzuru KOKIDO, Yoko HASHIMOTO, Tadashi YONEDA
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Abstract
A method of manufacturing a butanediol through 3-hydroxybutyryl-CoA that uses a microbe and/or a culture thereof and utilizes an enzyme reaction that is caused by an acyl-CoA reductase, wherein the microbe in the manufacturing method for a butanediol is characterized in that an activity of an acyl-CoA hydratase (EC number: 3. 1. 2. −) is deleted or reduced.
Claims12
A method of manufacturing a butanediol through 3-hydroxybutyryl-CoA that uses a microbe and/or a culture thereof and utilizes an enzyme reaction that is caused by an acyl-CoA reductase, wherein the microbe in the manufacturing method for a butanediol is characterized in that an activity of an acyl-CoA hydratase (EC number:
- 3. 1. 2. −) is deleted or reduced.
A fabrication method for a microbe for manufacturing a butanediol, characterized by including a process for deleting or reducing an activity of an acyl-CoA hydratase (EC number:
- 3. 1. 2. −) of a microbe.
A microbe that includes a gene that codes β-ketothiolase (EC number:
- 2. 3. 1. 9), a gene that codes 3-hydroxybutyryl-CoA dehydrogenase (EC number:
- 1. 1. 1. 35), and a gene that codes acyl-CoA reductase (EC number:
- 1. 2. 1. 10) and a deleted or reduced activity of an acyl-CoA hydratase (EC number:
- 3. 1. 2. −).
Dependencies are inferred from the claim text.