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US 2015/0307849 A1Published application
Highly efficient influenza matrix (m1) proteins
AssigneeNovavax, Inc.
InventorsGale SMITH, Yingyun WU, Michael MASSARE, Peter PUSHKO, Margaret NATHAN, Thomas KORT, Robin ROBINSON
Life of this patent
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Abstract
This invention discloses a method of increasing production of virus-like particles comprising expressing an avian influenza matrix protein. The invention also comprises methods of making and using said VLPs.
Claims17
1-20. (canceled)
A method of increasing expression of a VLP comprising expressing a mutated influenza M1 protein, an influenza HA protein, and an influenza NA protein in a host cell,
- wherein the mutated influenza M1 protein comprises an Arginine to Lysine mutation at the position corresponding to position 101 of SEQ ID NO:
- 49.
The method of claim 1 wherein the host cell is an insect cell.
Dependencies are inferred from the claim text.