T cell receptor-deficient t cell compositions
AssigneeTrustees of Dartmouth College
InventorCharles L. SENTMAN
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Abstract
The invention is directed to modified T cells, methods of making and using isolated, modified T cells, and methods of using these isolated, modified T cells to address diseases and disorders. In one embodiment, this invention broadly relates to TCR-deficient T cells, isolated populations thereof, and compositions comprising the same. In another embodiment of the invention, these TCR-deficient T cells are designed to express a functional non-TCR receptor. The invention also pertains to methods of making said TCR-deficient T cells, and methods of reducing or ameliorating, or preventing or treating, diseases and disorders using said TCR-deficient T cells, populations thereof, or compositions comprising the same.
Claims21
1-31. (canceled)
A method of producing a bank T cell receptor (TCR)-deficient T cells having different HLA haplotypes, comprising:
- obtaining a pool of isolated T cells having a specific HLA haplotype;
- expressing a TCR Inhibitory Molecule (TIM) in the T cells having the specific HLA haplotype that destabilizes the TCR complex by reducing or blocking expression of components of the TCR complex;
- and combining the pool of TCR-deficient T cells having the specific HLA haplotype with another pool of TCR-deficient T cells having another specific HLA haplotype, wherein said T cell bank comprises different T cell pools that each contain TCR-deficient T cells of a specific HLA type.
Dependencies are inferred from the claim text.