Polysialic Acid Derivatives
AssigneeLipoxen Technologies Limited
InventorsDale Howard Hreczuk-Hirst, Sanjay Jain, Peter Laing, Gregory Gregoriadis, Ioannis Papaioannou
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Abstract
A polysialic acid compound is reacted with a hetero-bifunctional reagent to introduce a pendant functional group for site-specific conjugation to sulfhydryl groups, for instance side chains of cysteine units in drugs, drug delivery systems, proteins or peptides. The functional group is, for instance, an N-maleimide group.
Claims20
A polysaccharide having at least two sialic acid units linked 2.8 and/or 2.9 to one another, comprising a compound having the general formula:
- X—R—Y
- in which:
- X is a N-maleimido, N-iodoacetamido, S-vinylsulphonyl or S-orthopyridyldisulphide group,
- R is alkane-diyl, arylene or aralkylene alkarylene, alkylene-oxaalkylene, or alkylene-oligooxa-alkylene or alkyl-oligopeptidyl-alkyl group;
- and
- Y is a hydrazide, amine or N-hydroxysuccinimide group.
A heterobifunctional reagent having a first functional group for reaction with sulfydryl groups and a second functional group different from the first group whereby the second functional group reacts with a terminal unit of a polysialic acid to form a covalent bond.
Dependencies are inferred from the claim text.