Single-domain antigen-binding proteins that bind mammalian igg
AssigneeBac IP B.V.
InventorsWilhelmus Josephus Johanna HERMANS, Sandra Bezemer, Yvonne Mathalie Mijnsbergen
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Abstract
The present application relates to antigen-binding proteins that are capable of binding to mammalian IgG. The frame-work regions of the antigen-binding proteins of the application preferably correspond to those of antibodies naturally that are devoid of light chains as may e.g. be found in camelids. The application further relates to nucleic acids that encode such antigen-binding proteins, to immunoadsorbent materials that comprise such proteins, to the uses of such immunoadsorbent materials for the purification of mammalian IgG antibodies and for therapeutic apheresis.
Claims13
1-44. (canceled)
An antigen-binding protein comprising an amino acid sequence that comprises 4 framework regions, FRI to FR4, and 3 complementarity determining regions, CDR1 to CDR3, that are operably linked in the order FR1-CDR1-FR2-CDR2-FR3-CDR3-FR4, wherein:
- a) the CDR1 has an amino acid sequence selected from the group consisting of SEQ ID No's:
- 1-49 or an amino acid sequence that differs from SEQ ID No's:
- 1-49 in one or two of the amino acid residues;
- b) the CDR2 has an amino acid sequence having at least 80% sequence identity with an amino acid sequence selected from the group consisting of SEQ ID No's:
- 50-98;
- and,
- c) the CDR3 is an amino acid sequence having at least 80% sequence identity with an amino acid sequence selected from the group consisting of SEQ ID No's:
- 99-147;
- and,
- wherein each of the framework regions has at least 50% amino acid identity with the framework amino acid sequence of any one of SEQ ID No's:
- 148-196, and wherein the antigen-binding protein specifically binds to the Fc domain of a mammalian IgG molecule.
Dependencies are inferred from the claim text.