Anti-cd98 antibody processes

An isolated monoclonal antibody or fragment thereof which specifically binds to a CD98 epitope bound by an antibody or fragment thereof that:

• (i) has the amino acid sequence of complementarity determining region (CDR)s comprised in (a) SEQ ID NOs:
• 41 and 47, (b) SEQ ID NOs:
• 43 and 47, (c) SEQ ID NOs:
• 43 and 77, (d) SEQ ID NOs:
• 43 and 79, (e) SEQ ID NOs:
• 43 and 81, (f) SEQ ID NOs:
• 43 and 83;
• and (g) SEQ ID NOs:
• 29 and 31,
• (ii) has the amino acid sequence of CDRs of the antibody produced by the cell line having a plasmid deposited under Accession Number FERM BP-10551 or a plasmid deposited under Accession Number FERM BP-10552, or
• (iii) has the amino acid sequence of CDRs encoded by a BglII-BsiWI fragment and a SalI-NheI fragment obtained from a plasmid vector K3/pCR4 deposited under Accession Number FERM BP-10552.

An isolated monoclonal antibody or fragment thereof which has:

• (i) the amino acid sequence of complementarity determining region (CDR)s comprised in (a) SEQ ID NOs:
• 41 and 47, (b) SEQ ID NOs:
• 43 and 47, (c) SEQ ID NOs:
• 43 and 77, (d) SEQ ID NOs:
• 43 and 79, (e) SEQ ID NOs:
• 43 and 81, (f) SEQ ID NOs:
• 43 and 83;
• and (g) SEQ ID NOs:
• 29 and 31,
• (ii) the amino acid sequence of CDRs of the antibody produced by the cell tine having a plasmid deposited under Accession Number FERM BP-10551 or a plasmid deposited under Accession Number FERM BP-10552, or
• (iii) the amino acid sequence of CDRs encoded by a BglII-BsiWI fragment and a SalI-NheI fragment obtained from a plasmid vector K3/pCR4 deposited under Accession Number FERM BP-10552.

An isolated monoclonal antibody or fragment thereof which has:

• (i) the amino acid sequence of variable regions comprised in (a) SEQ ID NOs:
• 41 and 47, (b) SEQ ID NOs:
• 43 and 47, (c) SEQ ID NOs:
• 43 and 77, (d) SEQ ID NOs:
• 43 and 79, (e) SEQ ID NOs:
• 43 and 81, (f) SEQ ID NOs:
• 43 and 83;
• and (g) SEQ ID NOs:
• 29 and 31,
• (ii) the amino acid sequence of variable regions of the antibody produced by the cell line having a plasmid deposited under Accession Number FERM BP-10551 or a plasmid deposited under Accession Number FERM BP-10552, or
• (iii) the amino acid sequence of variable regions encoded by a BglII-BsiWI fragment and a SalI-NheI fragment obtained from a plasmid vector K3/pCR4 deposited under Accession Number FERM BP-10552.