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US 2015/0307615 A1Published application
Humanized anti-interleukin 3 receptor alpha chain antibodies
AssigneeCSL Limited
InventorCon Panousis
Life of this patent
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Abstract
The present disclosure provides antibodies that bind to interleukin-3 receptor alpha chain and uses thereof.
Claims5
1-16. (canceled)
A method for inducing lysis of leukemic cells in a subject with acute myeloid leukemia (AML), the method comprising administering to a subject suffering from AML an isolated or recombinant antibody that is capable of specifically binding to interleukin (IL)-3Rα chain, wherein the antibody comprises:
- (i) a light chain variable region (VL) comprising CDRs 1, 2 and 3 as set forth in SEQ ID NOs:
- 2, 3 and 4, respectively;
- (ii) a heavy chain variable region (VH) comprising CDRs 1, 2 and 3 as set forth in SEQ ID NOs:
- 5, 6 and 7, respectively;
- and
- (iii) a heavy chain constant region comprising amino acid substitutions S239D and I332E according to the EU numbering system of Kabat.
3 more elements
Dependencies are inferred from the claim text.