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US 2015/0307614 A1Published application
Enhanced immunological responses
AssigneeDuke University
InventorsJohn H. Sampson, Duane A. Mitchell, Peter E. Fecci
Life of this patent
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Abstract
Cancers and other diseases can be treated with two or three types of agents: an agent which induces lymphodepletion or lymphopenia; an inhibitory antibody to a surface marker on Treg cells; and optionally a specific antigen. This combination may lead to enhanced immune responses despite lymphodepletion or lymphopenia.
Claims21
A method of treating a lymphodepleted subject, comprising:
- administering to the lymphodepleted subject an inhibitory antibody to IL-2Rα sufficient to inhibit Treg cells, whereby an immune response to a specific antigen is increased.
A kit for use in subjects lymphodepleted by disease or irradiation comprising:
- an inhibitory antibody to IL-2Rα and an immunogen.
Dependencies are inferred from the claim text.