Antibodies specific for soluble amyloid beta peptide protofibrils and uses thereof
AssigneeBioArctic Neuroscience AB
InventorsPär GELLERFORS, Lars LANNFELT
Life of this patent
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Abstract
The invention relates to an isolated monoclonal antibody or antigen-binding fragment thereof that (a) binds (i) wild-type Aβ 42/40 protofibril comprising N-terminal truncated Aβ forms and (ii) Aβ 42/40 Arc protofibril comprising N-terminal truncated Aβ forms and (b) has no or little cross-reactivity to Aβ 42/40 monomers. The invention further relates to a method of using such an antibody to treat Alzheimer's disease.
Claims9
An antibody specific for soluble amyloid beta peptide (Aβ) protofibrils and/or biologically active fragments thereof.
2-36. (canceled)
A method for lowering Aβ protofibril levels in the brain of a subject comprising administration to the subject an antibody or antigen-binding fragment thereof that binds Aβ40/42 arc protofibril and Aβ40/42 wild-type protofibril and has no or little cross-reactivity to Aβ40/42 monomers.
Dependencies are inferred from the claim text.