Anti-phf-tau antibodies and their uses
AssigneeJanssen Biotech, Inc.
InventorsChristopher Alderfer, Dariusz Janecki, Xueson Liu, Melissa Murdock, Sheng-Jiun Wu, Marc Mercken, Marc Vandermeeren, Thomas Malia
Life of this patent
Estimating the term…
Abstract
Anti-PHF-tau antibodies and methods of making and using them are disclosed.
Claims13
An isolated antibody that binds PHF-tau comprising an antigen-binding site of a heavy chain variable region (VH) of SEQ ID NO:35 or 37, and an antigen-binding site of a light chain variable region (VL) of SEQ ID NO:36 or 38.
An isolated antibody or fragment that competes for PHF-tau binding with a monoclonal antibody comprising an antigen-binding site of a VH of SEQ ID NO:35 and an antigen-binding site of a VL of SEQ ID NO:36, or an antigen-binding site of a VH of SEQ ID NO:37 and an antigen-binding site of a VL of SEQ ID NO:38.
An isolated polynucleotide encoding an antibody VH comprising HCDR1, HCDR2 and HCDR3 of SEQ ID NOs:7, 8 and 9, respectively, or SEQ ID NOs:13, 14 and 15, respectively.
An isolated polynucleotide encoding an antibody VL comprising LCDR1, LCDR2 and LCDR3 of SEQ ID NOs:10, 11 and 12, respectively, or SEQ ID NOs:16, 17 and 18, respectively.
Dependencies are inferred from the claim text.