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AssigneesBioquanta Corp., Assistance Publique-Hopitaux de Paris
InventorsMarc CONTI, Sylvain LORIC, Philippe MANIVET, Josselin CARADEC, Carolosse KEUMEUGNI KWEMO, Corine MATAR, Deborah REVAUD
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The present invention concerns a polypeptide comprising the N-terminal fragment of a cystatin, and/or a cystatin expression inducer for use for the treatment of sterility and/or infertility, and a method of diagnosing and/or predicting sterility and/or infertility of a subject and/or of a couple of subjects, which method comprises measuring the level of at least one cystatin in a biological sample of a male subject and/or measuring the level of at least one cystatin in a biological sample of a female subject, and optionally measuring further the level of at least one cathepsin in a biological sample of said male of female subject.
A polypeptide comprising N-terminal fragment of a cystatin, and/or a cystatin expression inducer for use for the treatment of sterility and/or infertility.
A polypeptide comprising N-terminal fragment of a cystatin, and/or cystatin expression inducer, for use as a fertilization promoting or improving drug.
A polypeptide comprising N-terminal fragment of a cystatin and/or cystatin expression inducer for use for promoting or improving the step of migration of a zygote from the fallopian tubes to the uterus in a female mammal.
A method of in vitro fertilization and/or artificial insemination comprising the steps of contacting an ovum obtained from a female mammal and a spermatozoon obtained from a male mammal in a fluid medium comprising a polypeptide comprising N-terminal fragment of a cystatin.
An in vitro method of diagnosing and/or predicting sterility and/or infertility of a subject and/or of a couple of subjects comprising the steps of:
A kit intended for diagnosing and/or predicting sterility and/or infertility of a subject and/or of a couple of subjects comprising:
A method of determining whether a subject and/or a couple of subjects suffering from sterility and/or infertility is likely to benefit from a treatment regimen that includes treatment with a ipolypeptide comprising N-terminal fragment of a cystatin and/or with a cystatin expression inducer comprising:
Dependencies are inferred from the claim text.