Peptidic antagonists of class iii semaphorins/neuropilins complexes

A peptidic antagonist of class III semaphorins/neuropilins complexes consisting of:

• a transmembrane domain of a protein selected from the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin beta 1 and integrin beta 2, wherein the transmembrane domain is optionally fused to a heterologous sequence, or
• an amino acid sequence of less than 50 amino acid long and more than 14 amino acid long having an identity of more than 80% with a transmembrane domain of a protein selected from the group consisting of neuropilin-1, neuropilin-2, plexin-A1, plexin-A2, plexin-A3, plexin-A4, Nr-CAM, L1-CAM, integrin beta 1 and integrin beta 2 and including at least one GxxxG motif, wherein the amino acid sequence of less than 50 amino acid long and more than 14 amino acid long retains the biological properties of the transmembrane domain and wherein the amino acid sequence of less than 50 amino acid long and more than 14 amino acid long is optionally fused to the heterologous sequence.