Chemokine-cytokine fusion proteins and their applications
AssigneeShiow-Her CHIOU
InventorsShiow-Her CHIOU, Kuan-Chih CHOW, Jui-Hung SHIEN, Yi-Hsin FAN, Pei-Hua LIN, Pei-Shan WU
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Abstract
The present invention provides a fusion protein, comprising a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof; and a cytokine polypeptide connected to said chemokine polypeptide, which is an interleukin, a TNF-superfamily cytokine or a receptor-binding domain thereof; wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.
Claims16
A fusion protein, comprising:
- a chemokine polypeptide, which is a chemokine or a receptor binding domain thereof;
- and
- a cytokine polypeptide connected to the chemokine polypeptide, which is a interleukin, a TNF-superfamily cytokine or a receptor binding domain thereof;
- wherein the chemokine polypeptide and the cytokine polypeptide have a common target cell, and the fusion protein has an improved chemokine activity as compared to the chemokine polypeptide, and an improved cytokine activity as compared to the cytokine polypeptide.
Dependencies are inferred from the claim text.