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US 2015/0307572 A1Published application
Bioactive peptides and methods of using same
AssigneeCompugen Ltd.
InventorsRonen Shemesh, Zurit Levine, Amir Toporik, Chen Hermesh, Yossef Kliger, Eyal Gofer, Assaf Wool, Dvir Dahary, Yossi Cohen
Life of this patent
Estimating the term…
Abstract
Disclosed are peptide ligands for G-protein coupled receptors that are useful for treating disorders associated with G-protein coupled receptor activation.
Claims21
1-21. (canceled)
A purified peptide less than 35 amino acids in length, said peptide comprising an amino acid sequence of Formula I:
- X1-X2-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-X13-X14-X15-X16-X17-X18-X19-X20-X21-X22-X23-X24-X25-X26-X27-X28-X29-X30-X31-X32-X33 wherein
- X1 is absent or G or a small naturally or non-naturally occurring amino acid;
- X2 is absent or Q or a polar naturally or non-naturally occurring amino acid;
- X3 is absent or K or a basic naturally or non-naturally occurring amino acid;
- X4 is absent or G or a small naturally or non-naturally occurring amino acid;
- X5 is absent or Q or S a polar naturally or non-naturally occurring amino acid;
- X6 is absent or V or A or P or M or a hydrophobic naturally or non-naturally occurring amino acid;
- X7 is absent or G or a small naturally or non-naturally occurring amino acid;
- X8 is absent or P or L or A or naturally or non-naturally occurring amino acid;
- X9 is absent or P or Q or a naturally or non-naturally occurring amino acid;
- X10 is absent or G or a small naturally or non-naturally occurring amino acid;
- X11 is absent or A or H or E or D or a hydrophobic or a small or an acidic naturally or non-naturally occurring amino acid;
- X12 is absent or A or P or Q or S or R or H or a hydrophobic or a small naturally or non-naturally occurring amino acid;
- X13 is absent or C or V or A or any amino acid other than C;
- X14 is absent or R or K or Q or P or a basic or a polar naturally or non-naturally occurring amino acid;
- X15 is absent or R or Q or S or a basic or a polar naturally or non-naturally occurring amino acid;
- X16 is absent or A or L or H or Q or a hydrophobic or a small naturally or non-naturally occurring amino acid;
- X17 is absent or Y or a hydrophobic or an aromatic naturally or non-naturally occurring amino acid;
- X18 is absent or A or a hydrophobic or small naturally or non-naturally occurring amino acid;
- X19 is absent or A or a hydrophobic small naturally or non-naturally occurring amino acid;
- X20 is absent or F or a hydrophobic or an aromatic naturally or non-naturally occurring amino acid;
- X21 is absent or S or T or a polar naturally or non-naturally occurring amino acid;
- X22 is absent or V or a hydrophobic naturally or non-naturally occurring amino acid;
- X23 is absent or G or hydrophobic or small naturally or non-naturally occurring amino acid or replaced by an Amide;
- X24 is absent or R or a basic naturally or non-naturally occurring amino acid;
- X25 is absent or R or a basic naturally or non-naturally occurring amino acid;
- X26 is A or a hydrophobic or small naturally or non-naturally occurring amino acid;
- X27 is Y or a hydrophobic or an aromatic naturally or non-naturally occurring amino acid;
- X28 is A or a hydrophobic or small naturally or non-naturally occurring amino acid;
- X29 is A or a hydrophobic or small naturally or non-naturally occurring amino acid;
- X30 is F or a hydrophobic naturally or non-naturally occurring amino acid;
- X31 is S or T or a polar naturally or non-naturally occurring amino acid;
- X32 is V or a hydrophobic naturally or non-naturally occurring amino acid;
- X33 is absent or G or hydrophobic or small naturally or non-naturally occurring amino acid or replaced by an amide;
- or a pharmaceutically acceptable salt thereof.
32 more elements
Dependencies are inferred from the claim text.