Peptidic chimeric antigen receptor t cell switches and uses thereof
AssigneeThe California Institute for Biomedical Research
InventorsTravis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ
Life of this patent
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Abstract
Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
Claims52
A chimeric antigen receptor-effector cell switch comprising:
- a. a peptidic antigen that binds a chimeric antigen receptor on an effector cell;
- and
- b. a targeting moiety that binds a cell surface molecule on a target cell.
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A pharmaceutical composition comprising:
- a. a chimeric antigen receptor-effector cell switch comprising:
- i. a peptidic antigen that binds a chimeric antigen receptor on an effector cell;
- and
- ii. a targeting moiety that binds a cell surface molecule on a target;
- and
- b. a pharmaceutically acceptable salt, excipient and/or vehicle.
A kit comprising:
- a. a chimeric antigen receptor-effector cell switch comprising:
- i. a peptidic antigen that binds a chimeric antigen receptor on an effector cell;
- and
- ii. a targeting moiety that binds a cell surface molecule on a target cell;
- and
- b. a chimeric antigen receptor-effector cell comprising a chimeric antigen receptor that binds to the peptidic antigen of the chimeric antigen receptor-effector cell switch.
-47. (canceled)
A chimeric antigen receptor that binds a peptidic antigen of a chimeric antigen receptor-effector cell switch.
-54. (canceled)
An effector cell comprising a chimeric antigen receptor, wherein the chimeric antigen receptor that binds a peptidic antigen of a chimeric antigen receptor-effector cell switch.
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A vector comprising a polynucleotide having a sequence that encodes a chimeric antigen receptor-effector cell switch, wherein the chimeric antigen receptor-effector cell switch comprises peptidic antigen and a targeting moiety, wherein the targeting moiety comprises a peptide and binds a cell surface molecule on a target cell.
A vector comprising a first polynucleotide having a first sequence that encodes a heavy chain of a targeting antibody or antibody fragment;
- a second polynucleotide having a second sequence that encodes a light chain of a targeting antibody or antibody fragment;
- and a third polynucleotide having a third sequence that encodes a peptidic antigen, wherein expression of the vector produces a chimeric antigen receptor-effector cell switch.
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A method of producing a chimeric antigen receptor-effector cell switch, comprising expressing from one or more polynucleotide vectors:
- a. a first sequence that encodes a heavy chain of a targeting antibody or antibody fragment;
- b. a second sequence that encodes a light chain of a targeting antibody or antibody fragment;
- and
- c. a third sequence that encodes a peptidic antigen, wherein expression of the vector produces a chimeric antigen receptor-effector cell switch.
Dependencies are inferred from the claim text.