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AssigneeCentro de Ingenieria Genetica y Biotecnologia
InventorsSantiago Dueñas Carrera, Daylen Aguilar Noriega, Yalena Amador Cañizares, Liz Alvarez-Lajonchere Ponce de León, Gillian Martínez Donato, Sonia Gonzalez Blanco
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The invention relates to chimeric vaccine antigens against hepatitis C virus (HCV) comprising selected regions of different antigens of said virus, which are placed in a pre-determined order inside the polypeptide. In addition, said chimeric antigens can include artificially formed specific epitopes for auxiliary T helper lymphocytes. The chimeric antigens and the resulting vaccine compositions are suitable for use in medicine and the pharmaceutical industry, as well as being suitable for prophylactic and/or therapeutic use against HCV. The vaccine compositions of the invention generate a powerful, broad-spectrum immune response against different antigens of the virus, with a minimum number of components.
A chimeric vaccine antigen against hepatitis C virus (HCV) comprising a) a first segment consisting of the E2 region (amino acids 408-540) of HCV polyprotein, b) a second segment consisting of the E1 region (amino acids 190-222) of HCV polyprotein, and c) a third segment consisting of the Core region (amino acids 1 to 50) of this protein, in this particular order.
A vaccine composition comprising a chimeric vaccine antigen against HCV comprising:
An epitope specific for T helper lymphocytes characterized in that it consists in SEQ ID No. 17 or SEQ ID No. 18.
Dependencies are inferred from the claim text.