US 2015/0307539 A1 · USE OF SULPHATED GLYCOLIPIDS AS PROMOTERS OF NEURITIC GROWTH, MYELINATION AND INHIBITING THE PROLIFERATION OF ASTROGLIA AND MICROGLIA

Use of sulphated glycolipids as promoters of neuritic growth, myelination and inhibiting the proliferation of astroglia and microglia

AssigneesConsejo Superior De Investigaciones Cientificas (Csic), Fundacion Del Hospital Nacional De Paraplejicos Para La Investigacion Y La Integracion (FUHNPAIIN)

InventorsManuel Nieto Sanpedro, Alfonso Fernandez Mayoralas, Ernesto Doncel Perez, Isabel Garcia Alvarez

Life of this patent

Estimating the term…

Abstract

A compound having formula I, in which R1 is an alkenyl group C5-C25 containing one or more double carbon-carbon bonds, R2 is selected independently from the group consisting of methyl and fluorinated methyl, and R3 and/or R4 is a SO3M group, in which M is selected from the group consisting of hydrogen, alkali metal, ammonium and quaternary amine, the other being hydrogen or acyl is provided. The compound can be used for the production of a drug for the treatment of central nervous system disorders selected from the group consisting of lesions caused by CNS trauma, demyelinating diseases, neuro-inflammatory diseases and mental disorders caused a low level of BDNF.

Claims21

Dependent claims

A compound having formula I

wherein
R1 is an alkenyl residue C5-C25 containing one or more double carbon-carbon bonds,
R2 is selected from the group consisting of methyl and fluorinated methyl, and
at least one of the substitutes R3 or R4 is an SO3M group, wherein M is selected from the group consisting of hydrogen, alkali metal, ammonium and quaternary amine, and the other substitute, if it is not an SO3M group, is selected from the group consisting of hydrogen and acyl.

1 more element

Dependencies are inferred from the claim text.