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US 2015/0307526 A1Published application
Guanidine-Functionalized Particles and Methods of Making and Using
Assignee3M Innovative Properties Company
InventorsGeorge W. Griesgraber, Robert T. Fitzsimons, JR., Douglas A. Hanggi, Masayuki Nakamura, Jerald K. Rasmussen
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Abstract
Guanidine-functionalized particles and methods of making and using such particles.
Claims30
A method of making a guanidine-functionalized particle, comprising:
- reacting O-methylisourea hemisulfate with a linker molecule comprising the formula
- (RO)nR3-na—Si—Sm—X
- where RO is an alkoxy group comprising one or two carbons, or is an acetoxy group,
- where n is 1, 2 or 3,
- where Ra is an unreactive group,
- where S is a spacer group comprising a backbone with m atoms,
- m is from 2-16, inclusive, and
- where X is a primary amine that is capable of reacting with the O-methylisourea to form a guanidine group;
- and,
- reacting at least one of the RO groups of the linker molecule with a hydroxyl group of the particle to form a covalent bond between the linker molecule and the particle.
7 more elements
A guanidine-functionalized silica gel particle, comprising:
- a silica gel particle comprising at least one ligand comprising a guanidine group, the ligand comprising the formula
- —OnSi—Sm-G,
- where —O is an oxygen atom that is covalently bonded to the surface of the silica gel particle,
- n is 1, 2 or 3,
- S is a spacer group comprising a backbone with m atoms,
- m is 2-16, inclusive,
- G is a guanidine group of the formula NH—C(NH)—NH2,
- and wherein the guanidine group is charged and comprises an associated counterion and wherein the counterion does not comprise a halogen.
5 more elements
A method of separating a target biological species from a fluid, comprising:
- contacting the fluid with a guanidine-functionalized particle;
- allowing the target biological species to non-specifically bind with a guanidine group of the guanidine-functionalized particle wherein the guanidine group is of the formula NH—C(NH)—NH2;
- and,
- separating the fluid and the guanidine-functionalized particle with the target biological species non-specifically bound thereto, from each other.
1 more element
Dependencies are inferred from the claim text.