Novel heteroaryl and heterocycle compounds, compositions and methods thereof

A compound of formula I-1, I-2 or I-3:

• and/or its solvates, racemic mixture, enantiomers, diasteromers, tautomers, or mixtures of any ratio, or pharmaceutically acceptable salts thereof, wherein:
• Z═N or CH;
• R1 is selected from optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, —(CR′R″)n-heterocycle, —(CR′R″)n-aryl, and —(CR′R″)n-heteroaryl, wherein heterocycle, aryl and heteroaryl independently are 5-6 membered monocyclic ring, which are optionally substituted with one or more groups selected from hydrogen, halo, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkoxyl, —CN, —CF3, and —SO2R′;
• R2 and R3 are each independently selected from hydrogen and optionally substituted C1-4 alkyl;
• R4 is selected from hydrogen, halo, —CN, optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, —C(O)NR′R″, and optionally substituted 5-6 membered monocyclic heteroaryl;
• R5 is selected from hydrogen and optionally substituted C1-4 alkyl;
• or R3, R5 and the atoms they are attached to form an optionally substituted 4-6 membered mono- or bicyclic saturated or partially unsaturated heterocyclic ring;
• R′ and R″ are each independently selected from hydrogen, halo, optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, and optionally substituted 4-6 membered monocyclic heterocycle;
• or R′, R″ and the nitrogen or carbon atom they are both attached to form an optionally substituted 3-7 membered heterocycle;
• each of m and n is 0, 1, 2, or 3;
• each of p is 1 or 2;
• W is a heteroaryl, which is optionally substituted with one or more groups selected from halo, —CN, —CF3, —NO2, —OR′, —NR′R″, —NR′COR″, —(CR′R″)n—C(O)R′, —(CR′R″)n—C(═N—OR′)—R″, —(CR′R″)n—C(O)NR′R″, —(CR′R″)n—S(O)pR′, —(CR′R″)n—SR′, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C1-6 alkoxy, optionally substituted 5-6 membered monocyclic heterocycle, and optionally substituted 5-6 membered monocyclic heteroaryl;
• provided that for formula I-1, when Z═N, R3, R5 and the atoms they are attached to must form an optionally substituted 4-6 membered mono- or bicyclic saturated or partially unsaturated heterocyclic ring, with the provision that when R3, R5 and the atoms they are attached to form an optionally substituted 5 membered mono- or bicyclic saturated or partially unsaturated heterocyclic ring, R4 is not hydrogen, —CN, or aminomethyl.