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US 2015/0307500 A1Published application
Inhibitors of bruton's tyrosine kinase
AssigneePharmacyclics, Inc.
InventorsLee HONIGBERG, Erik VERNER, Joseph J. BUGGY, David LOURY, Wei CHEN
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Abstract
Described herein are irreversible kinase inhibitor compounds, methods for synthesizing such irreversible inhibitors, and methods for using such irreversible inhibitors in the treatment of diseases. Further described herein are methods, assays and systems for determining an appropriate irreversible inhibitor of a protein, including a kinase.
Claims29
-100. (canceled)
A compound of Formula (A5) having the structure:
- wherein:
- R1 is -L2-(substituted or unsubstituted aryl), wherein L2 is a bond;
- R2 and R3 are H;
- R4 is L3-X-L4-G, wherein,
- L3 is substituted or unsubstituted alkyl;
- X is a bond;
- L4 is substituted or unsubstituted heterocycle;
- G is
- and
- R6, R7 and R8 are independently selected from among H, lower alkyl or substituted lower alkyl, lower heteroalkyl or substituted lower heteroalkyl, substituted or unsubstituted lower cycloalkyl, and substituted or unsubstituted lower heterocycloalkyl;
- or
- a pharmaceutically acceptable salt thereof.
9 more elements
Dependencies are inferred from the claim text.