Substituted triazolo-pyrimidine compounds for modulating cell proliferation, differentiation and survival

A compound of formula I,

• or pharmaceutically acceptable salts, solvates, and/or esters thereof, wherein:
• A is S, SO, SO2, O, NR4, C(R5R6)n, or bond;
• B is a member selected from substituted or unsubstituted C2-C8 alkylene, substituted or unsubstituted C2-C8 alkyleneoxy, substituted or unsubstituted C2-C8 alkylenesulfanyl, substituted or unsubstituted C2-C8 alkylenesulfinyl, substituted or unsubstituted C2-C8 alkylenesulfonyl, substituted or unsubstituted C2-C8 alkyleneamino, substituted or unsubstituted C3-C12 cycloalkylene, and substituted or unsubstituted C3-C12 heterocycloalkylene;
• C is a member selected from substituted or unsubstituted C3-C12 cycloalkyl, substituted or unsubstituted C3-C12 heterocycloalkyl, substituted or unsubstituted C6-C12 aryl and substituted or unsubstituted C5-C12 heteroaryl;
• R1 is a member selected from hydrogen, halo, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heterocycloalkyl;
• R2 is a member selected from hydrogen, halo, hydroxy, and substituted or unsubstituted alkyl;
• R3 is a member selected from hydrogen, halo, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heterocycloalkyl;
• and
• Each R4, R5, and R6 is independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted hydroxylakyl, substituted or unsubstituted alkoxyalkyl, substituted or unsubstituted aminoalkyl, substituted or unsubstituted alkylaminoalkyl, and substituted or unsubstituted dialkylaminoalkyl;
• and
• n is 0 to 3.

A compound of formula I

• or pharmaceutically acceptable salts, solvates, and/or esters thereof,
• wherein:
• A is S, SO, SO2, O, NR4, C(R5R6)n, or bond;
• B is a member selected from alkylene, alkyleneoxy, alkylenesulfanyl, alkylenesulfinyl, alkylenesulfonyl, alkyleneamino, alkylene(2-hydroxyethyl)amino, alkylene(2-acetyloxyethyl)amino, cycloalkylene, heterocycloalkylene, and alkylenecarbonylamino;
• C is a member selected from substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl, substituted or unsubstituted heteroaryl, and substituted or unsubstituted heteroaralkyl;
• R1 is a member selected from hydrogen, halo, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heterocycloalkyl;
• R2 is a member selected from hydrogen, halo, hydroxy, and substituted or unsubstituted alkyl;
• R3 is a member selected from hydrogen, halo, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted heterocycloalkyl;
• Each R4, R5, and R6 is independently selected from hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted hydroxylakyl, substituted or unsubstituted alkoxyalkyl, substituted or unsubstituted aminoalkyl, substituted or unsubstituted alkylaminoalkyl, and substituted or unsubstituted dialkylaminoalkyl;
• and
• n is 0 to 3.