Substituted pyridopyrazines as syk inhibitors

A compound of formula (I):

• and/or its racemic mixture, enantiomers, diastereomers, tautomers, or mixtures of optional ratio, or at least one pharmaceutically acceptable salt, or solvate thereof, wherein
• R1 is independently chosen from hydrogen, halo, —CN, —OH, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 alkoxy, —NH2, —NH(C1-C4 alkyl), and —N(C1-C4 alkyl)(C1-C4 alkyl);
• R2 is aryl, or heteroaryl, each of which is optionally substituted by one or more groups selected from halo, —NR5R6, —OR7, —S(O)nR8, —C(O)R9, —C(O)OR7, —CN, —C(O)NR5R6, —NR5C(O)R9, —NR5S(O)nR8, —NR5S(O)nNR10R11, —NR5C(O)OR7, —NR5C(O)NR10R11, —NO2, —S(O)nNR5R6, optionally substituted lower alkyl, optionally substituted cycloalkyl, optionally substituted heterocycle, optionally substituted heteroaryl, optionally substituted aryl, optionally substituted alkenyl, and optionally substituted alkynyl;
• L is a bond, or optionally substituted C1-C6 alkylene;
• W is cycloalkyl, heterocycle, aryl, or heteroaryl;
• R3 is independently selected from hydrogen, -Lx-halo, -Lx-R4, -Lx-NR5R6, -Lx-OR7, -Lx-S(O)nR8, -Lx-C(O)R9, —S(O)n-Lx-R8, —C(O)-Lx-R9, -Lx-C(O)OR7, -Lx-CN, -Lx-NR5C(O)R9, -Lx-NR5S(O)nR8, -Lx-NR5C(O)NR10R11, -Lx-NR5S(O)nNR10R11, Lx-NR5C(O)OR7, -Lx-NR5S(O)nOR7, —NO2, -Lx-C(O)NR5R6, -Lx-S(O)nNR5R6, oxo(═O), optionally substituted cycloalkyl, optionally substituted heterocycle, optionally substituted heteroaryl, and optionally substituted aryl,
• provided when L is methylene and W is 5- or 6-membered heterocycle, R3 is independently selected from -Lx-NR5R6, -Lx-OR7, -Lx-S(O)nR8, -Lx-C(O)R9, —S(O)n-Lx-R8, —C(O)-Lx-R9, -Lx-C(O)OR7, -Lx-CN, -Lx-NR5C(O)R9, -Lx-NR5S(O)nR8, -Lx-NR5C(O)NR10R11, -Lx-NR5S(O)nNR10R11, -Lx-NR5C(O)OR7, -Lx-NR5S(O)nOR7, —NO2, -Lx-C(O)NR5R6, -Lx-S(O)nNR5R6, oxo(═O), optionally substituted cycloalkyl, optionally substituted heterocycle, optionally substituted heteroaryl, and optionally substituted aryl;
• R4 is C1-C6alkyl, C2-C6alkenyl, or C2-C6alkynyl, each of which is optionally substituted;
• R5, R6, R7, R8, R9, R10, and R11 are independently selected from hydrogen, alkyl, cycloalkyl, aryl, heteroaryl, and heterocycle, each of which except for hydrogen, is optionally substituted with one or more groups selected from halo, —OH, —O(C1-C4 alkyl), —CN, C1-C4 alkyl, —NH2, —NH(C1-C4 alkyl), —N(C1-C4 alkyl)(C1-C4 alkyl), —C(O)NH2, —C(O)NH(C1-C4 alkyl), —C(O)N(C1-C4 alkyl)(C1-C4 alkyl), —C(O)(C1-C4 alkyl), —NHC(O)(C1-C4 alkyl), —N(C1-C4 alkyl)C(O)(C1-C4 alkyl), —S(O)nNH2, —S(O)nNH(C1-C4 alkyl), —S(O)nN(C1-C4 alkyl)(C1-C4 alkyl), —S(O)n(C1-C4 alkyl), —NHS(O)n(C1-C4 alkyl), —N(C1-C4 alkyl)S(O)n(C1-C4 alkyl), optionally substituted C3-C8 cycloalkyl, and optionally substituted 3-8 membered heterocycle, wherein C1-C4 alkyl is optionally substituted by halo, —OH, —OMe, —CN;
• or R5 and R6, R5 and R7, R5 and R8, R5 and R9, and R5and R10 together with the atom(s) to which they are attached can form a ring, which is optionally substituted with one or more groups selected from halo, —OH, —O(C1-C4 alkyl), —CN, C1-C4 alkyl, —NH2, —NH(C1-C4 alkyl), —N(C1-C4 alkyl)(C1-C4 alkyl), —C(O)NH2, —C(O)NH(C1-C4 alkyl), —C(O)N(C1-C4 alkyl)(C1-C4 alkyl), —C(O)(C1-C4 alkyl), —NHC(O)(C1-C4 alkyl), —N(C1-C4 alkyl)C(O)(C1-C4 alkyl), —S(O)nNH2, —S(O)nNH(C1-C4 alkyl), —S(O)nN(C1-C4 alkyl)(C1-C4 alkyl), —S(O)n(C1-C4 alkyl), —NHS(O)n(C1-C4 alkyl), —N(C1-C4 alkyl)S(O)n(C1-C4 alkyl), optionally substituted C3-C8 cycloalkyl, and optionally substituted 3-8 membered heterocycle, wherein C1-C4 alkyl is optionally substituted by halo, —OH, —OMe, or —CN;
• Lx is a bond, or optionally substituted C1-C6 alkylene;
• m is 0, 1 or 2,
• n is 1 or 2,
• p is 1, 2 or 3.