Process For the Preparation of Moxifloxacin Hydrochloride
AssigneeMankind Research Centre
InventorsHarish Sharma, Bhuwan Bhaskar, Anil Kumar
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Abstract
The present invention relates to an improved and industriously advantageous process by means of providing coupling/condensing of wet mass of (1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydro-3-quinoline carboxylic acid-O3,O4)bis(acyloxy-O)borate with (S,S)-2,8-diazabicyclo[4.3.0]nonane to give 1-cyclopropyl-7-[S,S]-2,8-diazabicyclo-[4.3.0]non-8-yl)-6-fluoro-1,4-dihydro-8-methoxy-4-oxo-3-quinoline carboxylic acid hydrochloride (Moxifloxacin hydrochloride) of Formula-I with high purity.
Claims11
A process for the preparation of moxifloxacin hydrochloride, comprising the steps of:
- (i) condensing a compound of Formula-II,
- with a compound of Formula-III,
- in presence of a base in a solvent system to produce an intermediate compound of Formula-IV,
- (ii) optionally isolating the compound of Formula-IV, and
- (iii) hydrolysing the compound of Formula-IV to form moxifloxacin hydrochloride,
- wherein the compound of Formula-II has a moisture content of about 10 to about 50%, and the solvent system comprises an organic solvent and water.
The process according to any of the preceding claims, wherein the amount of water in the said solvent system is about 5-60% by weight of the organic solvent(s).
Dependencies are inferred from the claim text.