Compounds useful for treating aids
AssigneesAbivax, Centre National De La Recherche Scientifique, Institut Curie, Universite De Montpellier
InventorsJamal TAZI, Florence MAHUTEAU, Romain NAJMAN, Didier SCHERRER, Noelie CAMPOS, Aude GARCEL
Life of this patent
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Abstract
A compound having the following formula or a pharmaceutically acceptable salt thereof: where: R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NR1R2 group, a (C1-C3)fluoroalkoxy group, a —NO2 group, a phenoxy group, or a (C1-C4)alkoxy group, R1 and R2 are independently a hydrogen atom or a (C1-C3)alkyl group, R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, or a (C1-C4)alkoxy group, R″ is a hydrogen atom or a (C1-C4)alkyl group, n is 1, 2, or 3, and n′ is 1 or 2.
Claims21
A compound having the following formula or a pharmaceutically acceptable salt thereof:
- where:
- R independently represents a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, a —NR1R2 group, a (C1-C3)fluoroalkoxy group, a —NO2 group, a phenoxy group, or a (C1-C4)alkoxy group,
- R1 and R2 are independently a hydrogen atom or a (C1-C3)alkyl group,
- R′ is a hydrogen atom, a halogen atom, a (C1-C3)alkyl group, or a (C1-C4)alkoxy group,
- R″ is a hydrogen atom or a (C1-C4)alkyl group,
- n is 1, 2, or 3, and
- n′ is 1 or 2.
A compound selected from the group consisting of:
- (8) Quinolin-2-yl-(4-trifluoromethoxy-phenyl)-amine,
- (75) 4-N-(8-chloroquinolin-2-yl)-1-N,1-N-dimethylbenzene-1,4-diamine,
- (77) 8-chloro-N-(4-methoxyphenyl)quinolin-2-amine,
- (78) 4-methyl-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (79) N-(4-methoxyphenyl)-3-methylquinolin-2-amine,
- (80) 3-methyl-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (81) 1-N,1-N-dimethyl-4-N-(3-methylquinolin-2-yl)benzene-1,4-diamine,
- (82) N-[2-methyl-4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (83) N-[3-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (84) N-[2-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (86) N-(3-fluorophenyl)quinolin-2-amine,
- (87) 8-chloro-N-[3-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (88) 8-chloro-N-(3-fluorophenyl)quinolin-2-amine,
- (89) 2-{[4-(trifluoromethoxy)phenyl]amino}quinolin-1-ium chloride,
- (90) 8-chloro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (91) 3-methyl-N-[2-methyl-4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (92) 3-methyl-N-[3-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (93) 3-methyl-N-[2-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (94) 8-chloro-N-[2-methyl-4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (95) 3-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}quinolin-1-ium chloride,
- (96) 6-chloro-N-(4-(trifluoromethoxy)phenyl)quinolin-2-amine,
- (97) 4-methyl-2-{[4-(trifluoromethoxy)phenyl]amino}quinolin-1-ium chloride,
- (98) 8-bromo-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (99) 8-fluoro-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (100) 8-methyl-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (101) N-(4-butoxyphenyl)-8-chloroquinolin-2-amine,
- (102) N-(4-phenoxyphenyl)quinolin-2-amine,
- (103) 8-methoxy-N-[4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (104) 8-chloro-N-[3-chloro-4-(trifluoromethoxy)phenyl]quinolin-2-amine,
- (155) N-(4-butoxyphenyl)-3-methylquinolin-2-amine,
- (156) 4-N-(6-chloroquinolin-2-yl)-1-N,1-N-dimethylbenzene-1,4-diamine,
- (157) 8-chloro-N-(3-chloro-4-methoxyphenyl)quinolin-2-amine,
- (158) N1-(8-chloroquinolin-2-yl)-4-(trifluoromethoxy)benzene-1,2-diamine, and
- their pharmaceutically acceptable salts.
Dependencies are inferred from the claim text.